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中华脑血管病杂志(电子版) ›› 2025, Vol. 19 ›› Issue (03) : 244 -249. doi: 10.3877/cma.j.issn.1673-9248.2025.03.011

所属专题: 文献

综述

细胞间黏附分子-1与卒中的相关性研究进展
马芬1, 王保爱2,()   
  1. 1 032200 山西 汾阳,山西医科大学汾阳学院
    2 032200 山西 汾阳,山西省汾阳医院 山西医科大学附属汾阳医院神经内科
  • 收稿日期:2024-09-12 出版日期:2025-06-01
  • 通信作者: 王保爱
  • 基金资助:
    山西省医学重点科研项目(2021XM41); 山西省吕梁市重点研发项目(2022SHFZ13)

Research advances in the association between intercellular adhesion molecule-1 and stroke

Fen Ma1, Baoai Wang,2()   

  1. 1 Fenyang College, Shanxi Medical University, Fenyang 032200, China
    2 Department of Neurology, Shanxi Province Fenyang Hospital, Fenyang Hospital affiliated to Shanxi Medical University, Fenyang 032200, China
  • Received:2024-09-12 Published:2025-06-01
  • Corresponding author: Baoai Wang
引用本文:

马芬, 王保爱. 细胞间黏附分子-1与卒中的相关性研究进展[J/OL]. 中华脑血管病杂志(电子版), 2025, 19(03): 244-249.

Fen Ma, Baoai Wang. Research advances in the association between intercellular adhesion molecule-1 and stroke[J/OL]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2025, 19(03): 244-249.

细胞间黏附分子-1(ICAM-1)属于免疫球蛋白超家族的成员,在血管内皮细胞表面广泛分布,是血管发生病变时最敏感的指标之一。已有研究表明,ICAM-1与卒中的发生、发展、治疗及预后有着密切关系。本文就近年来国内外对ICAM-1与卒中相关性的研究展开综述,总结疾病进展过程中ICAM-1发挥的调控作用及机制,并对其在卒中治疗中的应用及相关作用靶点进行阐述,以期为临床预防及治疗提供新思路。

Intercellular adhesion molecule-1 (ICAM-1), a member of the immunoglobulin superfamily, is widely expressed on the surfaces of vascular endothelial cells and is recognized as one of the most sensitive biomarkers in vascular pathology. Extensive studies have demonstrate a close relationship between ICAM-1 and the occurrence, progression, treatment, and prognosis of stroke. This review synthesizes recent global research on the interactions between ICAM-1 and stroke, summarizes the regulatory roles and mechanisms of ICAM-1 in disease progression, and elaborates on its potential therapeutic targets and clinical applications. The findings aim to provide new insights for stroke prevention and treatment strategies.

表1 ICAM-1在卒中治疗中的应用
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